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Peregrine Pharmaceuticals said it reached an agreement with the U.S. Food and Drug Administration on the design of a late-stage trial for its experimental lung cancer drug. _0"> The late-stage trial will compare a combination of chemotherapy and the drug, bavituximab, with chemotherapy alone. The main goal of the trial would be to show an improvement in overall survival of patients.   Peregrine shares were up 19 percent at $1.83 in early trade on Monday on the Nasdaq . Bavituximab is being developed to treat second-line non-small-cell lung cancer and multiple other cancers. "We look forward to finalizing the clinical protocol and initiating the global Phase III trial by year-end," Joseph Shan, vice president of clinical and regulatory affairs, said in a statement. Peregrine went through tough times last year after it found discrepancies in the results of a mid-stage trial testing bavituximab in non-small-cell lung cancer. Following the discovery of errors in

0 shares 5 View comments West Ham have reached an agreement with an offshore lending company in the British Virgin Islands to borrow all £60million of their next season's Premier League television money in advance, Inside Sport can reveal. The deal with the Vibrac Corporation was sealed six months ago on September 10, and the associated paperwork, which has been filed at Companies House, shows Vibrac have effectively become a 'payday loan' firm for the Hammers to help them manage their debts, which currently stand at a net £70m. Astonishingly, one source claims the practice of mortgaging TV revenue is becoming 'really common in the Premier League'. Betting on the future: West Ham owners David Gold (left) and David Sullivan He added: 'We think there are six other clubs currently doing it.' If West Ham retain their Premier League status as expected, their income from Premier League TV cash alone will be at least £60m in

0 View comments In a more stable era, Portsmouth's 2-0 win over Coventry in the battle of the financial basket cases in League One might have given them a glimmer of hope that they could yet escape relegation. And Coventry, despite a defeat meted out via goals from Jed Wallace and Patrick Agyemang, might reasonably still be hoping to bag a place in the play-offs and a shot at an immediate return to the Championship after relegation last spring. But this is no stable era. Coventry are pondering docked points - and no certainty where their team will even be playing their next home game. Play up Pompey: Portsmouth's Jed Wallace celebrates scoring the opener against Coventry Their owners Sisu, a hedge fund, have upped sticks and left the Ricoh Arena they rent. And it is extremely likely that Pompey, in administration for 13 months and counting, will be relegated anyway, consigned to fourth-tier football for the first time since 1980. And that is their

The U.S. Supreme Court on Monday agreed to hear a patent dispute concerning Medtronic Inc over medical devices it manufactures that give the heart electrical jolts when it fails to pump blood properly. Medtronic wants the Supreme Court to reverse an appeals court finding that it had the burden of showing that it was not infringing on patents owned by Mirowski Family Ventures LLC and licensed exclusively to Boston Scientific Corp.   The legal battle concerns devices, called cardiac resynchronization therapy, or CRT, which monitors the heart to ensure that the left and right ventricles contract at the same time. If they do not, electrical shocks restore a correct rhythm. The companies have an agreement in which Medtronic licensed the patents in question and agreed to pay royalties on new products if they were found to be using the patents. In 2007, Mirowski Family Ventures claimed Medtronic was developing new products that would justify royalty payments. Medtronic filed suit, seeki

0 shares 5 View comments Premier League footballers have invested an estimated £1billion over the past decade in ‘highly complex’ financial schemes that have left many bankrupt or with severe money headaches, according to a consultant who tries to recover fortunes lost as a result of mis-selling. Some of the most significant schemes are centred in the film industry and have been operated as legal tax avoidance tools. Big-name current and former footballers, including David Beckham, Wayne Rooney, Steven Gerrard, Robbie Keane, Emile Heskey, Frank Lampard, Robbie Savage, Jamie Carragher and Darius Vassell, are known to have invested in them, although there is no suggestion that any of these players have suffered problems. Star turn: David Beckham, a major investor in film industry schemes, meets young fans on a visit to China       More from Ni

16 shares 2 View comments Serious shortcomings in the way fake and rogue football agents are policed by the game’s authorities have been exposed after the Football Association were made aware of numerous players falling victim to hoaxers and losing out financially. The problem, ongoing and widespread, revolves around people pretending to be licensed agents and taking money from aspiring players, usually from abroad, to arrange trials at English clubs. The bogus agents thrive by building apparently authentic ‘profiles’ on social networks such as Facebook and Twitter and on the business network, LinkedIn. Scammed: Guyana international Vurlon Mills was tricked by a pretend FIFA agent     More from Nick Harris...   Nick Harris: Murray and Co chase £1.5m as Wimbledon chiefs raise prize money to record £20m 20/04/13

European investigators have asked top trading houses Glencore, Vitol and Gunvor to help with a probe into oil price manipulation, while not suggesting they are under investigation, industry sources said on Monday. _0"> Last week, European Commission authorities raided the London bureau of pricing agency Platts and the offices of oil majors Statoil, Royal Dutch Shell and BP in the biggest cross-border action since the probe into rigging of Libor benchmark interest rates.   The Commission said it was concerned that companies, which it did not name, might have colluded in reporting prices to Platts to manipulate published assessments for oil, refined products and biofuels and may have prevented others from participating in the assessment process. "We have been asked to cooperate with the investigation and provide information, so far very general. But it was also made clear to us that we are not being investigated," a source at one of the big trading houses said. S